Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites

Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

2016

Akiyoshi Fukamizu (University of Tsukuba) new

Daitoku, H., Kaneko, Y., Yoshimochi, K., Matsumoto, K., Araoi, S., Sakamaki, JI., Takahashi, Y., and *Fukamizu, A.
Non-transcriptional Function of FOXO1/DAF-16 Contributes to Translesion DNA Synthesis.
Mol Cell Biol. [Epub ahead of print]

Waku, T., *Nakajima, Y., Yokoyama, W., Nomura, N., Kako, K., Kobayashi, A., Shimizu, T., and Fukamizu, A.
NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.
J. Cell Sci. 129, 2382-2393 (2016)pubmed

Hashimoto, M., Murata, K., Ishida, J., Kanou, A., Kasuya, Y., and *Fukamizu, A.
Severe hypomyelination and developmental defects are caused in mice lacking protein arginine metyltransferase 1 (PRMT1) in the central nervous system.
J. Biol. Chem. 291, 2237-2245 (2016)pubmed

Toshiyuki Shimizu (The University of Tokyo)

Waku, T., *Nakajima, Y., Yokoyama, W., Nomura, N., Kako, K., Kobayashi, A., Shimizu, T.,and Fukamizu, A.
NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.
J. Cell Sci. 129, 2382-2393 (2016)pubmed

Toma-Fukai, S., Kim, J.D., Park, K.E., Kuwabara, N., Shimizu, N., Krayukuhina, E., Uchiyama, S., Fukamizu, A., and *Shimizu, T.
Novel helical assembly in arginine methyltransferase 8.
J Mol Biol. 428, 1197-1208 (2016)pubmed

Hozumi Motohashi (Tohoku University)

Honkura, Y., Matsuo, H., Murakami, S., Sakiyama, M., Mizutari, K., Shiotani, A., Yamamoto, M., Morita, I., Shinomiya, N., Kawase, T., Katori, Y.,and *Motohashi, H.
NRF2 is a key target for prevention of noise-induced hearing loss by reducing oxidative damage of cochlea
Sci Rep. 6, 19329 (2016)pubmed

Naoya Yahagi (University of Tsukuba)

Takeuchi, Y., *Yahagi, N., Aita, Y., Murayama, Y., Sawada, Y., Piao, X., Toya, N., Oya, Y., Shikama, A., Takarada, A., Masuda, Y., Nishi, M., Kubota, M., Izumida, Y., Yamamoto, T., Sekiya, M., Matsuzaka, T., Nakagawa, Y., Urayama, O., Kawakami, Y., Iizuka, Y., Gotoda, T., Itaka, K., Kataoka, K., Nagai, R., Kadowaki, T., Yamada, N., Lu, Y., Jain, MK.,and Shimano, H.
KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.
Cell Rep. 16, 2373-2386 (2016) pubmed

Juro Sakai(The University of Tokyo)new

Inagaki, T., Sakai, J., and *Kajimura, S.
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
Nat. Rev. Mol. Cell Biol. 17, 480-495 (2016)pubmed

Keisuke Nimura(Osaka University)new

*Nimura, K., Yamamoto, M., Takeichi, M., Saga, K., Takaoka, K., Kawamura, N., Nitta, H., Nagano, H., Ishino, S., Tanaka, T., Schwartz, RJ., Aburatani, H., and *Kaneda, Y.
Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development.
eLIFE e16030 (2016)pubmed

Jun Nakae(Keio University)

Kawano, Y., *Nakae, J., Watanabe, N., Kikuchi, T., Tateya, S., Tamori, Y., Kaneko, M., Abe, T., Onodera, M., and Itoh, H.
Colonic Pro-inflammatory Macrophages Cause Insulin Resistance in an Intestinal Ccl2/Ccr2-Dependent Manner.
Cell Metab. 24, 295–310 (2016)pubmed

Akira Kobayashi(Doshisha University)

Waku, T., *Nakajima, Y., Yokoyama, W., Nomura, N., Kako, K., Kobayashi, A., Shimizu, T.,and Fukamizu, A.
NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.
J. Cell Sci. 129, 2382-2393 (2016)pubmed