Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites

Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Research Projects

Management Committee

Head Investigator
  • Akiyoshi Fukamizu
    Professor
    Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba
Principal Investigators
  • Kazuhiko Igarashi
    Professor
    Tohoku University Graduate School of Medicine
  • Mitsuyoshi Nakao
    Professor
    Institute of Molecular Embryology and Genetics, Kumamoto University
  • Kaoru Sugasawa
    Professor
    Biosignal Research Center, Kobe University
  • Hozumi Motohashi
    Professor
    Department of Gene Expression Regulation, IDAC, Tohoku University 
  • Naoya Yahagi
    Associate Professor
    Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Toshiyuki Shimizu
    Professor
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
Advisors
  • Hiroyuki Sasaki
    Professor
    Kyushu University
  • Masato Kasuga
    Director-General
    Research Institute, National Center for Global Health and Medicine
  • Yoshihiro Yoneda 
    Professor
    Osaka University

Planned Research Projects

Click on each project title for details.

Project Title Fukamizu Group:
Crosstalk regulation between the formation of the transcriptional environment and amino acid metabolism
Principal Investigator akiyoshi Akiyoshi Fukamizu
Professor
Life Science Center, Tsukuba Advanced Research Alliance
University of Tsukuba
Web: http://akif2.tara.tsukuba.ac.jp/
E-mail:
Co-investigator takahasi-hidekazu-s05082-256x300 Hidekazu Takahashi
Associate Professor
Yamaguchi University Graduate School of Medicine
E-mail:

Project Title Igarashi Group:
Epigenetic role of the methionine metabolic pathway and its involvement in carcinogenesis
Principal Investigator Kazuhiko Igarashi Kazuhiko Igarashi
Professor
Tohoku University Graduate School of Medicine
Web: http://www.med.tohoku.ac.jp/english/org/medical/05/
E-mail:

Project Title Nakao Group:
Molecular basis of metabolic reprogramming mediated by chromatin factors
Principal Investigator Mitsuyoshi Nakao Mitsuyoshi Nakao
Professor
Institute of Molecular Embryology and Genetics
Kumamoto University
Web: http://www.imeg.kumamoto-u.ac.jp/en/
E-mail:
Co-investigator Shinjiro Hino Shinjiro Hino
Assistant Professor
Institute of Molecular Embryology and Genetics
Kumamoto University
E-mail:

Project Title Sugasawa Group:
Cross-regulation of the maintenance and mutagenesis of genomic sequence and epigenetic information
Principal Investigator Kaoru Sugasawa Kaoru Sugasawa
Professor
Biosignal Research Center, Kobe University
Web: http://www.research.kobe-u.ac.jp/brce-sugasawa/index-e.html
E-mail:

Project Title Motohashi Group:
Crosstalk between the oxidative stress response and metabolic regulation modulated by the chromatin environment
Principal Investigator hozumi-motohashi-236x300 Hozumi Motohashi
Professor
Department of Gene Expression Regulation, IDAC, 
Tohoku University 
HP: http://www2.idac.tohoku.ac.jp/dep/ger/
E-mail:

Project Title Yahagi Group:
Exploring the mechanisms of metabolic control of gene expression through new approaches of nutrigenomics
Principal Investigator Naoya Yahagi Naoya Yahagi
Associate Professor,
Graduate School of Comprehensive Human Sciences
University of Tsukuba
Web: http://metab.umin.ne.jp/index-e.shtml
E-mail:

Project Title Shimizu Group:
Structural analysis of the transcription environment factors that engage in crosstalk with metabolic pathways
Principal Investigator Toshiyuki Shimizu Toshiyuki Shimizu
Professor
Graduate School of Pharmaceutical Sciences
The University of Tokyo
HP: http://www.f.u-tokyo.ac.jp/~kouzou/index_e.html
E-mail:
Co-investigator Shoko Toma Sachiko Toma
Associate Professor
Graduate School of Pharmaceutical Sciences
The University of Tokyo
E-mail:
Co-investigator yuka nakajima Yuka Nakajima
Associate Professor
Life Science Center, Tsukuba Advanced Research Alliance
University of Tsukuba
E-mail: