Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites

Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

2014

Kazuhiko Igarashi(Tohoku University)

Itoh-Nakadai, A., Hikota, R., Muto, A., Kometani, K., Watanabe-Matsui, M., Sato, Y., Kobayashi, M., Nakamura, A., Miura, Y., Yano, Y., Tashiro, S., Sun, J., Ikawa, T., Ochiai, K., Kurosaki, T., and *Igarashi, K.
The transcription repressors Bach2 and Bach1 promote B cell development by repressing the myeloid program.
Nature Immunology 12,1171-1180 (2014)pubmed

*Igarashi, K., Ochiai, K., Itoh-Nakadai, A., and Muto, A.
Orchestration of plasma cell differentiation by Bach2 and its gene regulatory network.
Immunol. Rev. 261, 116-125 (2014)pubmed

Toshiyuki Shimizu (The University of Tokyo)、Akiyoshi Fukamizu (University of Tsukuba)

Hasegawa, M., Toma-Fukai, S., Kim, JD., Fukamizu, A. and *Shimizu, T.
Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats.
FEBS Lett. 588, 1942-1948 (2014)pubmed

Tsutomu Sasaki(Gunma University)

Sasaki, T., Kikuchi, O., Shimpuku, M., Susanti, VY., Yokota-Hashimoto, H., Taguchi, R., Shibusawa, N., Sato, T., Tang, L., Amano, K., Kitazumi, T., Kuroko, M., Fujita, Y., Maruyama, J., Lee, YS., Kobayashi, M., Nakagawa, T., Minokoshi, Y., Harada, A., Yamada, M., and *Kitamura, T.
Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.
Diabetologia 57, 819-831 (2014)pubmed