Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites

Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

Research Projects

Management Committee

Head Investigator
  • Akiyoshi Fukamizu
    Professor
    Life Science Center, Tsukuba Advanced Research Alliance, University of Tsukuba
Principal Investigators
  • Kazuhiko Igarashi
    Professor
    Tohoku University Graduate School of Medicine
  • Mitsuyoshi Nakao
    Professor
    Institute of Molecular Embryology and Genetics, Kumamoto University
  • Kaoru Sugasawa
    Professor
    Biosignal Research Center, Kobe University
  • Hozumi Motohashi
    Professor
    Department of Gene Expression Regulation, IDAC, Tohoku University
  • Naoya Yahagi
    Associate Professor
    Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • Toshiyuki Shimizu
    Professor
    Graduate School of Pharmaceutical Sciences, The University of Tokyo
Advisors
  • Hiroyuki Sasaki
    Professor
    Kyushu University
  • Masato Kasuga
    Director-General
    Research Institute, National Center for Global Health and Medicine
  • Yoshihiro Yoneda 
    Professor
    Osaka University

Planned Research Projects

Click on each project title for details.

Project Title Fukamizu Group:
Crosstalk regulation between the formation of the transcriptional environment and amino acid metabolism
Principal Investigator akiyoshi Akiyoshi Fukamizu
Professor
Life Science Center, Tsukuba Advanced Research Alliance
University of Tsukuba
Web: http://akif2.tara.tsukuba.ac.jp/
E-mail:
Co-investigator takahasi-hidekazu-s05082-256x300 Hidekazu Takahashi
Associate Professor
Yamaguchi University Graduate School of Medicine
E-mail:

Project Title Igarashi Group:
Epigenetic role of the methionine metabolic pathway and its involvement in carcinogenesis
Principal Investigator Kazuhiko Igarashi
Professor
Tohoku University Graduate School of Medicine
Web: http://www.med.tohoku.ac.jp/english/org/medical/05/
E-mail:

Project Title Nakao Group:
Molecular basis of metabolic reprogramming mediated by chromatin factors
Principal Investigator Mitsuyoshi Nakao
Professor
Institute of Molecular Embryology and Genetics
Kumamoto University
Web: http://www.imeg.kumamoto-u.ac.jp/en/
E-mail:
Co-investigator Shinjiro Hino
Assistant Professor
Institute of Molecular Embryology and Genetics
Kumamoto University
E-mail:

Project Title Sugasawa Group:
Cross-regulation of the maintenance and mutagenesis of genomic sequence and epigenetic information
Principal Investigator Kaoru Sugasawa
Professor
Biosignal Research Center, Kobe University
Web: http://www.research.kobe-u.ac.jp/brce-sugasawa/index-e.html
E-mail:

Project Title Motohashi Group:
Crosstalk between the oxidative stress response and metabolic regulation modulated by the chromatin environment
Principal Investigator hozumi-motohashi-236x300 Hozumi Motohashi
Professor
Department of Gene Expression Regulation, IDAC,
Tohoku University
HP: http://www2.idac.tohoku.ac.jp/dep/ger/
E-mail:

Project Title Yahagi Group:
Exploring the mechanisms of metabolic control of gene expression through new approaches of nutrigenomics
Principal Investigator Naoya Yahagi
Associate Professor,
Graduate School of Comprehensive Human Sciences
University of Tsukuba
Web: http://metab.umin.ne.jp/index-e.shtml
E-mail:

Project Title Shimizu Group:
Structural analysis of the transcription environment factors that engage in crosstalk with metabolic pathways
Principal Investigator Toshiyuki Shimizu
Professor
Graduate School of Pharmaceutical Sciences
The University of Tokyo
HP: http://www.f.u-tokyo.ac.jp/~kouzou/index_e.html
E-mail:
Co-investigator Sachiko Toma
Associate Professor
Graduate School of Pharmaceutical Sciences
The University of Tokyo
E-mail:
Co-investigator yuka nakajima Yuka Nakajima
Associate Professor
Life Science Center, Tsukuba Advanced Research Alliance
University of Tsukuba
E-mail: