2012
Akiyoshi Fukamizu (University of Tsukuba)
Co-Investigator；Hidekazu Takahashi (Okayama University)
Takahashi, H., Sun, X., Hamamoto, M., Yashiroda, Y., and *Yoshida, M.
The SAGA Histone Acetyltransferase Complex Regulates Leucine Uptake through the Agp3 Permease in Fission Yeast.
J. Biol. Chem. 287, 38158-38167 (2012)
Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., Wild, B, Camargo, SM., Singer, D., Richter, A., Kuba, K., Fukamizu, A., Schreiber, S., Clevers, H., Verrey, F., *Rosenstiel, P., and *Penninger, JM.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Nature. 487, 477-481 (2012)
Ozcan, L., Wong, CC., Li, G., Xu, T., Pajvani.,U., Park, SK., Wronska, A., Chen, BX., Marks, AR., Fukamizu, A., Backs, J., Singer, HA., Yates, JR 3rd., Accili, D., and *Tabas, I.
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.
Cell Metab. 15, 739-751 (2012)
Sakamaki, JI., Daitoku, H., Kaneko, Y., Hagiwara, A., Ueno, K., and *Fukamizu, A.
GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1.
J. Recept. Signal Transduct. 32, 96-101 (2012)
Kazuhiko Igarashi (Tohoku University)
Li, J., Shiraki, T., and *Igarashi, K.
Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism.
FEBS Lett. 586(4), 448-454 (2012)
Mitsuyoshi Nakao (Kumamoto University)
*Hino, S., Sakamoto, A., Nagaoka, K., Anan, K., Wang, Y., Mimasu, S., Umehara, T., Yokoyama, S., Kosai, K., and *Nakao, M.
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure.
Nature Commun. 3, Article number 758 (2012)
Junn Yanagisawa (University of Tsukuba)
Kuwabara, N., Oyama, T., Tomioka, D., Ohashi, M., Yanagisawa, J., Shimizu, T., and *Miyachi, H.
Peroxisome Proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: Phenypropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J. Med. Chem. 55, 893-902 (2012)
Toshiyuki Shimizu (The University of Tokyo)
Ohto, U., Usui, K., Ochi, T., Yuki, K., Satow, Y., and *Shimizu, T.
Crystal Structure of Human β-Galactosidase: The Structural Basis of GM1 Gangliosidosis and Morquio B Diseases.
J. Biol. Chem. 287, 1801-1812 (2012)
Usui, K., *Ohto, U., Ochi, T., Shimizu, T., and *Satow, Y.
Expression, purification, crystallisation and preliminary X-ray crystallographic analysis of human β-Galactosidase.
Acta Crystallogr. F68, 73-77 (2012)
Hozumi Motohashi (Tohoku University)
Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., *Yamamoto, M., and *Motohashi, H.
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Cancer Cell. 22, 66-79 (2012)
Yamazaki, H., Katsuoka, F., Motohashi, H., Engel, JD., and *Yamamoto, M.
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
Mol. Cell. Biol. 32, 808-816 (2012)
Yoshiki Hayashi（National Institute for Basic Biology)
Hayashi, Y., Sexton, TR., Dejima, K., Perry, DW., Takemura, M., Kobayashi, S., *Nakato, H., and*Harrison, DA.
Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen.
Development 139, 4162-4171 (2012)