生命素子による転写環境とエネルギー代謝のクロストーク制御(転写代謝システム)

文部科学省 科学研究費補助金「新学術領域研究」平成23年度~27年度

2015

深水 昭吉(筑波大学)

Kim, JD., Park, KE., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., and *Fukamizu, A.
PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.
Sci. Adv. 11, e1500615 (2015)pubmed

Kako, K., Nakamura, A., Nagashima, Y., Ishida, J.,and *Fukamizu, A.
Detection of ethanolamine altering in fetuses of pregnancy-associated hypertensive mice treated with vasodepressors by using UPLC and MALDI-TOF/MS.
J. Chromatogr B Analyt Technol Biomed Life Sci. 1006, 93-98 (2015)pubmed

中尾 光善(熊本大学)、連携研究者;日野 信次朗(熊本大学)

Nagaoka, K., *Hino, S., Sakamoto, A., Anan, K., Takase, R., Umehara, T., Yokoyama, S., Sasaki, Y., and *Nakao, M.
Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells.
Mol. Cell. Biol. 35, 1068-1080 (2015)pubmed

Sakamoto, A., *Hino, S., Nagaoka, K., Anan, K., Takase, R., Matsumori, H., Ojima, H., Kanai, Y., Arita, K., and *Nakao, M.
Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.
Cancer Res. 75, 1445-1456 (2015)pubmed

西川 恵三(大阪大学)

 *Nishikawa, K., Iwamoto, Y., Kobayashi, Y., Katsuoka, F., Kawaguchi, S., Tsujita, T., Nakamura, T., Kato, S., Yamamoto, M., Takayanagi, H., and *Ishii, M.
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.
Nat.Med. 21, 281- 287 (2015)pubmed

酒井 寿郎(東京大学)

*Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., and *Sakai, J.
H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation
Mol. Cell 60, 584-596 (2015)pubmed

*Inagaki, T., Iwasaki, S., Matsumura, Y., Kawamura, T., Tanaka, T., Abe, Y., Yamasaki, A., Tsurutani, Y., Yoshida, A., Chikaoka, Y., Nakamura, K., Magoori, K., Nakaki, R., Osborne, TF., Fukami, K., Aburatani, H., Kodama, T., and *Sakai, J. 
The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
J. Biol. Chem. 290, 4163- 4177 (2015)pubmed

Abe, Y., Rozqie, R., Matsumura, Y., Kawamura, T., Nakaki, R., Tsurutani, Y., Tanimura-Inagaki, K., Shiono, A., Magoori, K., Nakamura, K., Ogi, S., Kajimura, S., Kimura, H., Tanaka, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., *Inagaki, T., and *Sakai, J. 
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat. Commun. 6, 7052 (2015) pubmed

清水 宣明(東京大学)、尾池 雄一(熊本大学)

Shimizu, N., Maruyama, T., Yoshikawa, N., Matsumiya, R., Ma, Y., Ito, N., Tasaka, Y., Kuribara-Souta, A., Miyata, K., Oike, Y., Berger, S., Schütz, G., Takeda, S., and *Tanaka, H.
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.
Nat. Commun. 6, 6693 (2015)pubmed

櫛引 俊宏(防衛医科大学校)

*Kushibiki, T., Okawa, S., Hirasawa, T., and Ishihara, M.
Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo.
Gene Ther. 7, 553-559 (2015)pubmed

中井 彰(山口大学)

Tan, K., Fujimoto, M., Takii, R., Takaki, E., Hayashida, N., and *Nakai, A.
Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity.
Nat. Commun. 6, 6580 (2014)pubmed