Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites

Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

2011(KH)

Kaoru Sugasawa (Kobe University)

Fischer, ES., Scrima, A., Böhm, K., Matsumoto, S., Lingaraju, GM., Faty, M., Yasuda, T., Cavadini, S., Wakasugi, M., Hanaoka, F., Iwai, S., Gut, H., Sugasawa, K., and *Thomä, NH.
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.

Cell 147, 1024-1039 (2011)    pubmed       

Yanagihara, H., Kobayashi, J., Tateishi, S., Kato, A., Matsuura, S., Tauchi, H., Yamada, K., Takezawa, J., Sugasawa, K., Masutani, C., Hanaoka, F., Weemaes, CM., and Mori, T., Zou, L., and *Komatsu, K.
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Mol. Cell 43, 788-797 (2011)
    pubmed

Toshiyuki Shimizu (The University of Tokyo)

Ohto, U., Miyake, K., and *Shimizu, T.
Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family
.
J. Mol. Biol. 413, 815-825 (2011)    pubmed   

Kokabu, Y., Murayama, Y., Kuwabara, N., Oroguchi, T., Hashimoto, H., Tsutsui, Y., Nozaki, N., Akashi, S., Unzai, S., Shimizu, T., Iwasaki, H., Sato, M., and *Ikeguchi, M.
The fission yeast Swi5-Sfr1 complex, an activator of Rad51 recombinase, forms an extremely elongated Dogleg-shaped structure.
J. Biol. Chem. 286, 43569-43576 (2011)    pubmed   

Hozumi Motohashi (Tohoku University)

Uruno, A., and *Motohashi, H.
 The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
Nitric Oxide 25, 153-160 (2011)    pubmed

Naoya Yahagi (University of Tsukuba)

Kumadaki, S., Karasawa, T., Matsuzaka, T., Ema, M., Nakagawa, Y., Nakakuki, M., Saito, R., Yahagi, N., Iwasaki, H., Sone, H., Takekoshi, K., Yatoh, S., Kobayashi, K., Takahashi, A., Suzuki, H., Takahashi, S., Yamada, N., and *Shimano, H.
Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.

J. Biol. Chem. 286, 40835-40846 (2011)    pubmed