Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites

Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

2013

Mitsuyoshi Nakao(Kumamoto University )
Co-Investigator;Shinjiro Hino(Kumamoto University) new

*Hino, S., Nagaoka, and Nakao, M.
Metabolism-epigenome crosstalk in physiology and diseases.
J. Hum. Genet. 58, 410-415 (2013)pubmed

Akiyoshi Fukamizu (University of Tsukuba)
Co-Investigator;Hidekazu Takahashi (Yamaguchi University)

Tamiya, H., Hirota, K., Takahashi, Y., Daitoku, H., Kaneko, Y., Sakuta, G., Iizaka, K., Watanabe, S., Ishii, N., and *Fukamizu, A.
Conserved SAMS function in regulating egg-laying in C. elegans 
J. Recept. Signal Transduct. 33, 56-62 (2013)pubmed

Toshiyuki Shimizu(The University of Tokyo)

Tanji, H., Ohto, U., Shibata, T., Miyake, K., *Shimizu, T.
Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.
Science 339,1426-1429 (2013)pubmed

Kazuhiko Igarashi(The Tohoku University )

Nakamura, A., Ebina-Shibuya, R., Itoh-Nakadai, A., Muto, A., Shima, H., Saigusa, D., Aoki, J., Ebina, M., Nukiwa, T., and *Igarashi, K.
Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.
J. Exp. Med. 210, 2191-2204 (2013)pubmed

Kera, Y., Katoh, Y., Ohata, M., Matsumoto, M., Takano-Yamamoto, T., *Igarashi, K.
Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.
J Biol Chem. 288,13592-13601 (2013)pubmed

Naoya Yahagi(University of Tsukuba)

Izumida, Y., *Yahagi, N., Takeuchi ,Y., Nishi, M., Shikama, A., Takarada, A., Masuda, Y., Kubota, M., Matsuzaka, T., Nakagawa, Y., Iizuka, Y., Itaka, K., Kataoka, K., Shioda, S., Niijima, A., Yamada, T., Katagiri, H., Nagai, R., Yamada, N., Kadowaki, T., and Shimano H. 
Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization.
Nature Commun. 4, Article number 2316 (2013)pubmed

Koh Ono(kyoto University)

Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Sowa, N., Yahagi, N., Shimano, H., Matsumura, S., Inoue, K., Marusawa, H., Nakamura, T., Hasegawa, K., Kume, N., Yokode, M., Kita, T., Kimura, T., and *Ono, K.
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.
Nat. Commun. 4, 2883 (2013)pubmed

Kazuhiro Ikeda(Saitama Medical University Reseatch Center for Genomic Medicine)

Ikeda, K., Shiba, S., Horie-Inoue, K., Shimokata, K.,and *Inoue, S.
A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle.
Nat. Commun. 4, 2147 (2013)pubmed

Tsuyoshi Osawa(The University of Tokyo)

*Osawa, T., Tsuchida, R., Muramatsu, M., Shimamura, T., Wang, F., Suehiro, J., Kanki, Y., Wada, Y., Yuasa, Y., Aburatani, H., Miyano, S., Minami, T., Kodama, T., and *Shibuya, M.
Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages.
Cancer Res. 73, 3019-3028 (2013)pubmed

Yasushi Ishihama(Kyoto University)

Yamana, R., Iwasaki, M., Wakabayashi, M., Nakagawa, M., Yamanaka, S.,and *Ishihama, Y.
Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot NanoLC-MS/MS analysis with meter-scale monolithic silica columns.
J. Proteome Res. 12, 214-221 (2013)pubmed