生命素子による転写環境とエネルギー代謝のクロストーク制御(転写代謝システム)

文部科学省 科学研究費補助金「新学術領域研究」平成23年度~27年度

2011

菅澤 薫(神戸大学)

Fischer, ES., Scrima, A., Böhm, K., Matsumoto, S., Lingaraju, GM., Faty, M., Yasuda, T., Cavadini, S., Wakasugi, M., Hanaoka, F., Iwai, S., Gut, H., Sugasawa, K., and *Thomä, NH.
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.
Cell 147, 1024-1039 (2011) pubmed       

Yanagihara, H., Kobayashi, J., Tateishi, S., Kato, A., Matsuura, S., Tauchi, H., Yamada, K., Takezawa, J., Sugasawa, K., Masutani, C., Hanaoka, F., Weemaes, CM., and Mori, T., Zou, L., and *Komatsu, K.
NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol η-dependent translesion DNA synthesis.
Mol. Cell 43, 788-797 (2011)pubmed

柳澤 純(筑波大学)

Goto, N., Hiyoshi, H., Ito, I., Tsuchiya, M., Nakajima, Y., and *Yanagisawa, J.
Estrogen and antiestrogens alter breast cancer invasiveness by modulating TGF-b signaling pathway.
Cancer Sci. 102, 1501-1508 (2011)pubmed

Kajiro, M., Tsuchiya, M., Kawabe, Y., Furumai, R., Iwasaki, N., Hayashi, Y., Katano, M., Nakajima, Y., Goto, N., Watanabe, T., Murayama, A., Oishi, H., Ema, M., Takahashi, S., Kishimoto, H., and *Yanagisawa, J.
The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.
PLoS One 6, e25871 (2011)
pubmed

清水 敏之(東京大学)

Ohto, U., Miyake, K., and *Shimizu, T.
Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
J. Mol. Biol. 413, 815-825 (2011) pubmed   

Kokabu, Y., Murayama, Y., Kuwabara, N., Oroguchi, T., Hashimoto, H., Tsutsui, Y., Nozaki, N., Akashi, S., Unzai, S., Shimizu, T., Iwasaki, H., Sato, M., and *Ikeguchi, M.
The fission yeast Swi5-Sfr1 complex, an activator of Rad51 recombinase, forms an extremely elongated Dogleg-shaped structure.
J. Biol. Chem. 286, 43569-43576 (2011)pubmed   

本橋 ほづみ(東北大学)

Uruno, A., and *Motohashi, H.
The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
Nitric Oxide 25, 153-160 (2011)pubmed

矢作 直也(筑波大学)

Kumadaki, S., Karasawa, T., Matsuzaka, T., Ema, M., Nakagawa, Y., Nakakuki, M., Saito, R., Yahagi, N., Iwasaki, H., Sone, H., Takekoshi, K., Yatoh, S., Kobayashi, K., Takahashi, A., Suzuki, H., Takahashi, S., Yamada, N., and *Shimano, H.
Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.
J. Biol. Chem. 286, 40835-40846 (2011)pubmed