生命素子による転写環境とエネルギー代謝のクロストーク制御(転写代謝システム)

文部科学省 科学研究費補助金「新学術領域研究」平成23年度~27年度

2013

中尾 光善(熊本大学)、連携研究者 ;日野 信次朗(熊本大学)

Hino, S., Nagaoka, and *Nakao, M.
Metabolism-epigenome crosstalk in physiology and diseases.
J. Hum. Genet.
58, 410-415 (2013) pubmed

深水 昭吉(筑波大学)、研究分担者;高橋 秀和(山口大学)

Tamiya, H., Hirota, K., Takahashi, Y., Daitoku, H., Kaneko, Y., Sakuta, G., Iizaka, K., Watanabe, S., Ishii, N., and *Fukamizu, A.
Conserved SAMS function in regulating egg-laying in C. elegans .
J. Recept. Signal Transduct
 33, 56-62 (2013)   pubmed

清水 敏之(東京大学)

Tanji, H., Ohto, U., Shibata, T., Miyake, K., and *Shimizu, T.
Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.
Science 339, 1426-1429 (2013)  pubmed

五十嵐 和彦(東北大学)

Nakamura, A., Ebina-Shibuya, R., Itoh-Nakadai, A., Muto, A., Shima, H., Saigusa, D., Aoki, J., Ebina, M., Nukiwa, T., and *Igarashi, K.
Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.
J. Exp. Med. 210, 2191-2204 (2013)  pubmed

Kera, Y., Katoh, Y., Ohata, M., Matsumoto, M., Takano-Yamamoto, T., and *Igarashi, K.
Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.
J. Biol. Chem. 288, 13592-13601 (2013)  pubmed

矢作 直也(筑波大学)

Izumida, Y., *Yahagi, N., Takeuchi ,Y., Nishi, M., Shikama, A., Takarada, A., Masuda, Y., Kubota, M., Matsuzaka, T., Nakagawa, Y., Iizuka, Y., Itaka, K., Kataoka, K., Shioda, S., Niijima, A., Yamada, T., Katagiri, H., Nagai, R., Yamada, N., Kadowaki, T., and Shimano H. 
Glycogen shortage during fasting triggers liver-brain-adipose neurocircuitry to facilitate fat utilization.
Nat. Commun. 4, Article number 2316 (2013)  pubmed

尾野 亘(京都大学)

Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Sowa, N., Yahagi, N., Shimano, H., Matsumura, S., Inoue, K., Marusawa, H., Nakamura, T., Hasegawa, K., Kume, N., Yokode, M., Kita, T., Kimura, T., and *Ono, K.
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.
Nat. Commun. 4, 2883 (2013)pubmed

池田 和博(埼玉医科大学ゲノム医学研究センター)

Ikeda, K., Shiba, S., Horie-Inoue, K., Shimokata, K.,and *Inoue, S.
A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle.
Nat. Commun. 4, 2147 (2013)pubmed

大澤 毅 (東京大学)

*Osawa, T., Tsuchida, R., Muramatsu, M., Shimamura, T., Wang, F., Suehiro, J., Kanki, Y., Wada, Y., Yuasa, Y., Aburatani, H., Miyano, S., Minami, T., Kodama, T., and *Shibuya, M.
Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages.
Cancer Res. 73, 3019-3028 (2013)pubmed

石濱 泰 (京都大学)

Yamana, R., Iwasaki, M., Wakabayashi, M., Nakagawa, M., Yamanaka, S.,and *Ishihama, Y.
Rapid and deep profiling of human induced pluripotent stem cell proteome by one-shot NanoLC-MS/MS analysis with meter-scale monolithic silica columns.
J. Proteome Res. 12, 214-221 (2013)pubmed