生命素子による転写環境とエネルギー代謝のクロストーク制御(転写代謝システム)

文部科学省 科学研究費補助金「新学術領域研究」平成23年度~27年度

2012

深水 昭吉(筑波大学)、研究分担者;高橋 秀和(岡山大学)

Takahashi, H., Sun, X., Hamamoto, M., Yashiroda, Y., and*Yoshida, M.
The SAGA Histone Acetyltransferase Complex Regulates Leucine Uptake through the Agp3 Permease in Fission Yeast.
J. Biol. Chem. 287, 38158-38167 (2012) pubmed

Hashimoto, T., Perlot, T., Rehman, A., Trichereau, J., Ishiguro, H., Paolino, M., Sigl, V., Hanada, T., Hanada, R., Lipinski, S., Wild, B, Camargo, SM., Singer, D., Richter, A., Kuba, K., Fukamizu, A., Schreiber, S., Clevers, H., Verrey, F., *Rosenstiel, P., and *Penninger, JM.
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Nature  487, 477-481 (2012) pubmed

Ozcan, L., Wong, CC., Li, G., Xu, T., Pajvani.,U., Park, SK., Wronska, A., Chen, BX., Marks, AR., Fukamizu, A., Backs, J., Singer, HA., Yates, JR 3rd., Accili, D., and *Tabas, I.
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. 
Cell Metab. 15, 739-751 (2012) pubmed

Sakamaki, JI., Daitoku, H., Kaneko, Y., Hagiwara, A., Ueno, K., and *Fukamizu, A.
GSK3 regulates gluconeogenic gene expression through HNF4α and FOXO1.  
J. Recept. Signal Transduct. 32, 96-101 (2012) pubmed

五十嵐 和彦(東北大学)

Li, J., Shiraki, T., and *Igarashi, K. 
Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism. 
FEBS Lett. 586(4), 448-454 (2012) pubmed

中尾 光善(熊本大学)

*Hino, S., Sakamoto, A., Nagaoka, K., Anan, K., Wang, Y., Mimasu, S., Umehara, T., Yokoyama, S., Kosai, K., and *Nakao, M.
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. 
Nat. Commun. 3, Article number 758 (2012) pubmed

柳澤 純(筑波大学)

Kuwabara, N., Oyama, T., Tomioka, D., Ohashi, M., Yanagisawa, J., Shimizu, T., and *Miyachi, H. 
Peroxisome Proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: Phenypropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J. Med. Chem. 55, 893-902 (2012) pubmed

pubmed 

清水 敏之(東京大学)

Ohto, U., Usui, K., Ochi, T., Yuki, K., Satow, Y., and *Shimizu, T.
Crystal Structure of Human β-Galactosidase: The Structural Basis of GM1 Gangliosidosis and Morquio B Diseases.
J. Biol. Chem. 287, 1801-1812 (2012) pubmed   

Usui, K., *Ohto, U., Ochi, T., Shimizu, T., and *Satow, Y.
Expression, purification, crystallisation and preliminary X-ray crystallographic analysis of human β-Galactosidase.
Acta Crystallogr. F68, 73-77 (2012) pubmed

本橋 ほづみ(東北大学)

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., *Yamamoto, M., and *Motohashi, H.
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.
Cancer Cell. 22, 66-79 (2012) pubmed 

Yamazaki, H., Katsuoka, F., Motohashi, H., Engel, JD., and *Yamamoto, M.
Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins.
Mol. Cell. Biol. 32, 808-816 (2012) pubmed 

林 良樹(自然科学研究機構 基礎生物学研究所)

Hayashi, Y., Sexton, TR., Dejima, K., Perry, DW., Takemura, M., Kobayashi, S., *Nakato, H., and*Harrison, DA.
Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen.
Development  139, 4162-4171 (2012)pubmed