Crosstalk between transcriptional control and energy pathways, mediated by hub metabolites

Scientific Research on Innovative Areas, a MEXT Grant-in-Aid Project FY2011-2015

2015

Akiyoshi Fukamizu(University of Tsukuba)

Kim, JD., Park, KE., Ishida, J., Kako, K., Hamada, J., Kani, S., Takeuchi, M., Namiki, K., Fukui, H., Fukuhara, S., Hibi, M., Kobayashi, M., Kanaho, Y., Kasuya, Y., Mochizuki, N., and *Fukamizu, A.
PRMT8 as a phospholipase regulates Purkinje cell dendritic arborization and motor coordination.
Sci Adv.11, e1500615 (2015)pubmed

Mitsuyoshi Nakao(Kumamoto University )
Co-Investigator;Shinjiro Hino(Kumamoto University)

Nagaoka, K., *Hino, S., Sakamoto, A., Anan, K., Takase, R., Umehara, T., Yokoyama, S., Sasaki, Y., and *Nakao, M.
Lysine-specific demethylase LSD2 suppresses lipid influx and metabolism in hepatic cells.
Mol. Cell. Biol. 35,1068-1080 (2015)pubmed

Sakamoto, A., *Hino, S., Nagaoka, K., Anan, K., Takase, R., Matsumori, H., Ojima, H., Kanai, Y., Arita, K., and *Nakao, M.
Lysine demethylase LSD1 coordinates glycolytic and mitochondrial metabolism in hepatocellular carcinoma cells.
Cancer Res. 75,1445-1456 (2015)pubmed

Keizo Nishikawa(Osaka University)

 *Nishikawa, K., Iwamoto, Y., Kobayashi, Y., Katsuoka, F., Kawaguchi, S., Tsujita, T., Nakamura, T., Kato, S., Yamamoto, M., Takayanagi, H., and *Ishii, M.
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.
Nat.Med. 21, 281- 287 (2015)pubmed

Juro Sakai(The University of Tokyo)

*Matsumura, Y., Nakaki, R., Inagaki, T., Yoshida, A., Kano, Y., Kimura, H., Tanaka, T., Tsutsumi, S., Nakao, M., Doi, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., and *Sakai, J.
H3K4/H3K9me3 Bivalent Chromatin Domains Targeted by Lineage-Specific DNA Methylation Pauses Adipocyte Differentiation
Mol. Cell 60, 584-596 (2015)pubmed

*Inagaki, T., Iwasaki, S., Matsumura, Y., Kawamura, T., Tanaka, T., Abe, Y., Yamasaki, A., Tsurutani, Y., Yoshida, A., Chikaoka, Y., Nakamura, K., Magoori, K., Nakaki, R., Osborne, TF., Fukami, K., Aburatani, H., Kodama, T., and *Sakai, J. 
The FBXL10/KDM2B scaffolding protein associates with novel polycomb repressive complex-1 to regulate adipogenesis.
J. Biol. Chem. 290, 4163- 4177 (2015)pubmed

Abe, Y., Rozqie, R., Matsumura, Y., Kawamura, T., Nakaki, R., Tsurutani, Y., Tanimura-Inagaki, K., Shiono, A., Magoori, K., Nakamura, K., Ogi, S., Kajimura, S., Kimura, H., Tanaka, T., Fukami, K., Osborne, TF., Kodama, T., Aburatani, H., *Inagaki, T., and *Sakai, J. 
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Nat. Commun. 6, 7052 (2015)pubmed

Noriaki Shimizu(The University of Tokyo)、Yuichi Oike(Kumamoto University)

Shimizu, N., Maruyama, T., Yoshikawa, N., Matsumiya, R., Ma, Y., Ito, N., Tasaka, Y., Kuribara-Souta, A., Miyata, K., Oike, Y., Berger, S., Schütz, G., Takeda, S., and *Tanaka, H.
A muscle-liver-fat signalling axis is essential for central control of adaptive adipose remodelling.
Nat. Commun. 6, 6693 (2015)pubmed

Toshihiro Kushibiki(National Defense Medical College)

*Kushibiki, T., Okawa, S., Hirasawa, T., and Ishihara, M.
Optogenetic control of insulin secretion by pancreatic β-cells in vitro and in vivo.
Gene Ther. 7, 553-559 (2015)pubmed

Akira Nakai(Yamaguchi University)

Tan, K., Fujimoto, M., Takii, R., Takaki, E., Hayashida, N., and *Nakai, A.
Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity.
Nat. Commun. 6, 6580 (2014)pubmed